With high doses of corticosteroids, live or live-attenuated vaccines should be delayed until several months after corticosteroid treatment has stopped. May not be suitable for some people including those with cardiovascular disease, low thyroid levels, gastrointestinal disease, pre-exisiting bone disease, or psychiatric disorders. May interact with a number of other drugs including some anti-infectives, antidiabetic agents, bupropion, NSAIDs, and drugs metabolized by CYP 3A4 liver enzymes. Note: In general, seniors or children, people with certain medical conditions (such as liver or kidney problems, heart disease, diabetes, seizures) or people who take other medications are more at risk of developing a wider range of side effects. View complete list of side effects. Prednisone effectively controls inflammation and an overactive immune system but may not be suitable for everybody. Long-term use is limited by potentially severe side effects such as adrenal suppression and an increased risk of infection. Prednisone should always be used at the lowest effective dose for the shortest possible time. Take with food and a full glass of water to reduce the risk of prednisone adversely affecting your stomach. Single doses are preferred over split doses; however, larger dosages may be split. Some people may be instructed to only take prednisone every other day (alternate day therapy). Take prednisone in the morning, before 9 AM (unless instructed otherwise) to more closely mimic your body’s natural secretion of cortisol. Take your prednisone exactly as directed by your doctor. Never increase the dosage unless under your doctor’s advice. Stopping prednisone suddenly can be dangerous. Your doctor will advise you on how to taper down your prednisone dose if you have been taking it for more than a few weeks. If you are taking higher dosages of prednisone, you should not receive any live or live-attenuated vaccines. Your response to killed or inactivated vaccines may also be diminished. Avoid contact with anybody known to have, or recently exposed to, viral illnesses such as chickenpox or measles. If you inadvertently come into contact with somebody, contact your doctor immediately as immune globulin or antiviral treatment may be required. Limit or avoid alcohol use while taking prednisone to help reduce the risk of indigestion and the development of stomach ulcers, anavar joints. Talk with your doctor as soon as possible if you are taking prednisone and you become unwell, for any reason. Prednisone takes approximately 60 minutes to be metabolized in the liver to its active form, prednisolone. Liver disease does not appear to affect metabolism. Effects can last from 18-36 hours, meaning that alternate day dosing is possible.
Your physician or surgeon may not feel you need to take the extra steroid at the time of surgery, but if they know you have been on corticosteroids they can watch you more carefully after surgery, anavar joints.
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